In addition, the prevalence of cutaneous necrosis among the patients with anti-MDA5 Abs was higher than that among the patients with anti-Jo-1 Abs, which is consistent with a previous study's finding that anti-MDA5 Abs are associated with a unique cutaneous phenotype comprising cutaneous necrosis/ulceration, tender palmar papules, and ILD [14–16]. The gene discussed is IFIH1; the disease is interstitial lung disease.