IDH1 and acute myeloid leukemia: Terminal differentiation of erythroid cells can be influenced by ROS: a recent study showed that, when enzyme Isocitrate Dehydrogenase 1 (IDH1) is downregulated or knocked out, as in some IDH1 mutated AML and MDS, the oxidative stress induces the synthesis of dysplastic erythroblasts with morphological abnormalities, as double nuclei.