Mechanistic detail regarding the possible role of BCATc and BCAA metabolism in the TME of glioblastoma reveals that glioblastoma cells, expressing high levels of BCATc, excrete significant amounts of BCKAs via the monocarboxylate transporter 1 (MCT1), which is located near the BCATc enzyme [85]. The gene discussed is BCAT1; the disease is glioblastoma.