IDH1 and glioblastoma: While investigation regarding the status of the BCATc enzyme reaction under hypoxic TME conditions is currently lacking, the mechanism of silencing of BCATc in IDH1 mutant type glioblastoma includes a depletion of α-KG and extensive DNA hypermethylation of the main promoter region of the gene encoding BCATc in IDH1 mutant type of glioblastoma [18].