However, garlic could exert the therapeutic and protective effects through inhibition of obesity-induced (a) inflammation, (b) oxidative damage, (c) in apoptosis testis tissue, (d) enhancement testosterone synthesis by increasing the expression genes of StAR, P450scc, and 17BHSD or decreasing P450aromatase expression, (e) strengthening the activity of the pituitary-gonadal axis, and (f) modulating glucose and lipid metabolism by targeting the expression of genes with a role in lipogenesis and oxidation of fatty acid in the liver tissue. The gene discussed is STAR; the disease is obesity due to melanocortin 4 receptor deficiency.