Pathophysiological characteristics reflect the advanced NASH stage of F4 patients, as indicated by mean AST and ALT values in the low thirties, ELF scores ranging between 9.7 and 10.4, and relatively high values for Pro-C3 (22.6 to 25.6 μg/L) and liver stiffness (22.1 to 25.8 kPa). The gene discussed is GPT; the disease is metabolic dysfunction-associated steatohepatitis.