Given the reduction of liver fibrosis by efruxifermin, as indicated by histology and serum-based markers of soft tissue fibrosis, i.e., ELF score and Pro-C3, decreases in P1NP may be attributable to reduced synthesis of fibrils (type-I and -III collagen) and extracellular matrix (type-I and -IV collagen) in the liver.39 Here, SGCG is linked to Hepatic fibrosis.