Several risk factors for stage III CRC recurrence have been identified, including rectal cancer, preoperative and postoperative serum carcinoembryonic antigen (CEA) level (>5.0 ng/mL), postoperative carbohydrate antigen 19-9 level, infiltrative growth patterns, and >3 metastatic lymph nodes [6–8]. The gene discussed is CEACAM5; the disease is rectal cancer.