TGFB1 and inborn error of immunity: Meanwhile, we analyzed the main pathways in high ICI scores, such as adherens junction, cell cycle, Hedgehog signaling pathway, TGF-β signaling pathway, and Wnt signaling pathway, while the main pathways in the low ICI score were the B cell receptor signaling pathway, drug metabolism cytochrome P450, intestinal immune network for IgA production, primary immunodeficiency, and T cell receptor according to KEGG (Figure 2(i)).