Plasma lipopolysaccharides concentration leads to vascular endothelial dysfunction by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase pathway mediated by toll-like receptor-4 (TLR4) by generating reactive oxygen species (ROS) and following endothelial nitric oxide synthase (eNOS) deactivation and decreased endothelial nitric oxide (NO) bioavailability leading to endothelial dysfunction [11]. The gene discussed is NOS3; the disease is endothelial dysfunction.