In previous studies, PCP4 mRNA level is upregulated in OD of BMSCs [62]; PCP4 potentiates proliferation and differentiation of osteoblasts by blocking the c-Jun NH2-terminal kinase signaling pathway [63]; PCP4 knockdown suppresses OD of BMSCs in the progression of osteoporosis [35]; mechanically, PCP4 serves as a positive regulator of proosteogenic Runx2 in odontoblast differentiation of root progenitor cells [64]. This evidence concerns the gene RUNX2 and osteoporosis.