Collectively, our findings identified a novel mechanism of SNHG14 in OD of BMSCs wherein SNHG14 induces HuR-mediated upregulation of NEDD4L to repress FOXA2 expression through ubiquitination modification and upregulate PCP4 transcription, thereby facilitating OD of BMSCs. Here, PCP4 is linked to osteochondritis dissecans.