In liver fibrogenesis, the tissue inhibitor of metalloproteinase (TIMP) is expressed by activated HSCs, a specific inhibitor of MMPs, whereas MSCs could reduce liver fibrosis by upregulating MMPs, such as MMP-2, MMP-9, and MMP-13 [69], or by downregulating the expression of TIMP [70]. Here, TIMP1 is linked to Hepatic fibrosis.