In a study by Schweizer et al, 14 of these men were treated with high-dose testosterone injections every 4 weeks while on anti-androgen therapy, resulting in supraphysiological testosterone concentrations followed by castrate testosterone concentrations as the testosterone injection wore off.23 Treatment with BAT demonstrated a 50% reduction in PSA and 50% improvement in radiographic response of the metastatic prostate cancer. Here, KLK3 is linked to metastatic prostate carcinoma.