Rare variants in CFI and CFH associated with AMD (Supplemental Tables 3, 4) [FI: I340T (13, 20, 30–32), R406H (13, 16, 30, 31), K441R (13, 16, 30, 31), P553S (13, 16, 30, 31) and FH CCP 1-4: P26S (33), T91S (33), R166W (33), R232Q (33)] were modelled within the context of the AP regulatory TMC (25) (Figure 1). This evidence concerns the gene CFI and age-related macular degeneration.