The level of Notch2 expression in GBM is associated with stem genes (nestin and SRY-Box Transcription Factor-2), fate genes (expected outcome of normal development), astrocytes (vimentin and Glial Fibrillary Acidic Protein), and anti-apoptotic proteins (BCL6 and BCL-W) but is inversely related to Oligodendrocyte Transcription Factor-2 (Olig2), C-type natriuretic peptide (CNP), and PLP1 (oligodendrocyte fate) and proapoptotic proteins (apoptosis promoters) such as Bcl-2-associated X protein and Bcl-2-associated transcription factor 1 [30,31]. The gene discussed is NOTCH2; the disease is glioblastoma.