PTEN may contribute to gliomagenesis and survival by impairing proliferation, migration, invasion, angiogenesis, stem cell self-renewal, and regulation of other tumor suppressor pathways such as P53, poorly associated with glioblastoma [91,92,93,94,95].It has been observed that Notch1 and Notch2 have different effects on PI3k-Akt signaling with opposed regulation of PTEN, which was confirmed by protein and mRNA level analysis. This evidence concerns the gene NOTCH2 and glioblastoma.