AKT1 and glioblastoma: In a single-gene therapy study and multi-gene combinatorial therapy on EGFR, PI3K, AKT, and PTEN in GBM, Han et al. reported that PTEN was upregulated by adenoviral-mediated PTEN (Ad-PTEN), and PI3K was suppressed by LY294002 (Figure-1, Figure-2) [95,97,98].