In a study of the malignant mesothelioma, an invasive tumor of the pleura, pericardium, and peritoneum, Notch2 negatively regulated PI3k-Akt and found that Notch2 could activate PTEN, both of which inhibition of angiogenesis plays a pivotal role [28]. Here, NOTCH2 is linked to malignant mesothelioma.