These latter findings of nuclear AT1R on the ovine renal cortex support extensive evidence for an intracellular RAS within various tissues although the exact role of an activated intracellular RAS to influence cardiovascular disease and other pathologies is unknown and awaits more conclusive studies [38–40].Nevertheless, peptidase resistant and cell permeable agonists of the Ang-(1–7) axis may provide additional cardioprotective effects to conventional approaches to block the RAS. The gene discussed is AGTR1; the disease is cardiovascular disorder.