Complement C5a decreased in T2D from 30-min to 4-h versus baseline, with the most significant decrease at 2-h, post-hypoglycemia (30-min, p < 0.05; 1-h, p < 0.05; 2-h, p < 0.001; 4-h, p < 0.05); a decrease was also seen in controls at 2-h post-hypoglycemia (p = 0.05) (Fig. 4E). This evidence concerns the gene C5 and type 2 diabetes mellitus.