At hypoglycaemia, Complement C2 (p < 0.05) and Factor B (p < 0.01) remained elevated, whilst Factor I became elevated (p < 0.05) in the T2D cohort (Fig. 2C); by contrast, Complement C4b became elevated in controls (p < 0.05) (Fig. 2D). This evidence concerns the gene C2 and type 2 diabetes mellitus.