S100A1 and androgen insensitivity syndrome: Given that S100A1 and S100B proteins might function in a common signalling pathway in vivo (Ercole et al., 2016; Heizmann, 2019; Afanador et al., 2014), it was acceptable to posit that the S100A1 protein might be utilized in some capacity for disease diagnosis or reaction to the severity of AIS.