ADH5, NUDT7, PTGES3, D2HGDH, HAO2 and CPT1C also play regulatory roles in the pathological processes of various tumours (Adekeye et al., 2022; Han et al., 2018; Song et al., 2020; Li et al., 2021; Gaudet et al., 2011; Xiao et al., 2019). This evidence concerns the gene D2HGDH and neoplasm.