CD274 and Herpesviridae infectious disease: Lastly, for MF, hub genes were primarily interested in growth factor receptor binding, nonmembrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity, cytokine binding, etc. KEGG analysis showed that DEGs were primarily enriched in the Kaposi sarcoma−associated herpesvirus infection, Th17 cell differentiation, PD−L1 expression, and PD−1 checkpoint pathway in cancer, necroptosis, JAK−STAT signaling pathway, etc. (Figures 3(b) and 3(c)).