PRDX2 and neoplasm: A small part of the RBC’s Prx2 pool is located in thecellmembrane, where it has been associated with the cytoplasmic domainof a band 3 anion transport protein, spectrin, and the Gardos channel.97−99 Although the function of Prx2 in the RBC membrane is still elusive,the increase of membrane-bound Prx2 is a marker of RBC oxidation andstress.100,101 Interestingly, Prx2 also exhibits functionsoutside the RBC, as an enhancer of the cytotoxic activity of naturalkiller cells against tumor cells and as a proinflammatory cytokinethat is excreted in exosomes.102,103