As shown in Figures 9A–D, a total of seven immune cell populations that are related to all four core genes, of which naive B cells, resting memory CD4 T cells, regulatory T cells, and activated dendritic cells were statistically negatively with IL10RA, CD45, CTSS, and C1QA, while gamma delta T cells, monocytes, M0 macrophages, and M1 macrophages were positively correlated with them, suggesting they may play essential roles in CKD development. This evidence concerns the gene CD4 and chronic kidney disease.