Similarly, mild mitoribosomal stress in mouse hypothalamic proopiomelanocortin neurons has been demonstrated to upregulate MOTS‐c, which coordinated responses to induce thermogenesis and a cell non‐autonomous mitochondrial unfolded protein response in distal adipose tissues and protected from obesity (Kang, Min, et al., 2021). The gene discussed is MT-RNR1; the disease is obesity due to melanocortin 4 receptor deficiency.