Similar to HN, the plasma levels of MOTS‐c have been reported to be reduced in obesity and diabetes (Lee et al., 2015; Ramanjaneya et al., 2019) and correcting them prevented aging‐related and diet‐induced obesity and insulin resistance in mice (Lee et al., 2015). The gene discussed is MT-RNR1; the disease is obesity due to melanocortin 4 receptor deficiency.