Mitochondria‐derived peptides have also been linked to cardiovascular risk factors but circulating levels of HN and MOTS‐c were downregulated in people with coronary endothelial dysfunction (Qin, Delrio, et al., 2018; Widmer et al., 2013) and low‐circulating MOTS‐c or HN levels were associated with increased risk of cardiac events in type 2 diabetes (Ikonomidis et al., 2020) or angina patients (Cai et al., 2022), respectively. This evidence concerns the gene MT-RNR2 and type 2 diabetes mellitus.