In cell and mouse models of cancer cachexia, GDF15 in tumor‐derived exosomes was reported to directly contribute to muscle wasting (Zhang et al., 2022), and localized overexpression of GDF15 in mouse skeletal muscle by electroporation caused atrophy (Patel et al., 2016), offering evidence to link GDF15 to muscle mass regulation in addition to anorexia. Here, GDF15 is linked to neoplasm.