GDF15 and heart failure: While GDF15 on one hand may attenuate aging‐related inflammation (Conte et al., 2022; Moon et al., 2020), a mechanism probably involved in the pathogenesis of many age‐related diseases (Franceschi & Campisi, 2014), high GDF15 levels are associated with a more adverse outcome in heart failure patients, representing an even superior (adverse) biomarker in these patients than NT‐proB‐type Natriuretic Peptide (NT‐proBNP; Mendez Fernandez et al., 2020).