In recent years, the functional role of MCU in diverse diseases, such as cancerogenesis, heart failure, neurodegeneration, and muscle diseases, has been intensively investigated, and many inhibitors targeted to MCU have been developed for the treatment of these diseases.[21] Regarding the abundant existence and importance of mitochondria in liver tissues, the close interaction between mitochondrial Ca2+ signaling and liver diseases has attracted increasing attention, implying the crucial role of MCU in these mitochondria‐associated liver diseases. The gene discussed is MCU; the disease is heart failure.