HSPGs like syndecan‐3, syndecan‐4, glypican‐1, glypican‐3, or perlecan likely inhibit monomer wash‐out during medium changes.[188, 189] Some brain ECM proteins have been shown to decrease amyloid deposition and Aβ fibril formation in vitro, especially laminin.[207, 208, 209] Simpson and colleagues recently reported that high contents of laminin in Matrigel (≈60%) prevents Aβ fibril formation in vitro.[210] However, since Matrigel has been used successfully in AD models, the high laminin content might be counteracted by other components like HSPGs.[10]. The gene discussed is HSPG2; the disease is Alzheimer disease.