HMGB1 and cancer: There are several advantages for utilizing F1,6P to target HMGB1: First, HMGB1 KO mice are lethal, but F1,6P administration in mice has no obvious side effect; second, F1,6P treatment usually play a cytotoxic effect in cancer cells but a cytoprotective effect in various primary cells; third, HMGB1 is elevated in multiple tumors but plays paradoxical roles.