Even though numerous TRP channels are expressed in beta cells, only a few have been connected to insulin secretion,[19] and even less have been shown to have functional significance in islets in vivo.[7, 8, 31, 33] Pharmacological inhibition of TRPC3 but not TRPC6, and its deletion in mice, resulted in glucose intolerance and defective insulin secretion, with substantially lower plasma insulin levels in both the first and second phases of insulin secretion. This evidence concerns the gene INS and Glucose intolerance.