INS and diabetes mellitus: These findings do not diverge but rather point to a convergent mechanism in which Trpc3−/− mice peripheral tissues have a typical postprandial insulin action but a greater sensitivity during fasting; this phenotype is consistent with glucose intolerance observed in prediabetes but does not yet fit overt diabetes.[64] These observations are complemented by the identical insulin sensitivity test curves obtained in our study between WT and Trpc3−/− mice after adjusting blood glucose levels to baseline.