Of the 26 proteins whose levels were altered due to Ch‐ in both NonTg Ch‐ versus NonTg ChN and 3xTg‐AD Ch‐ versus 3xTg‐AD ChN comparisons (Figure 6f; Figure S2), 6 were upregulated, 4 were downregulated, and 16 were expressed in opposing directions. Here, C4B is linked to Alzheimer disease.