Interestingly Nptn, a critical protein for long‐term potentiation at Hp excitatory synapses, also linked to AD (Ilic et al., 2019), was downregulated in 3xTg‐AD ChN mice compared to NonTg ChN counterparts (Log2 FC = −1.55), and Ch‐ downregulated this protein in both NonTg (Log2 FC = −2.13) and 3xTg‐AD mice (Log2 FC = −3.44). This evidence concerns the gene HP and Alzheimer disease.