Of the 34 proteins that were differentially abundant due to Ch‐ in both NonTg Ch‐ vs. NonTg ChN and 3xTg‐AD Ch‐ vs. 3xTg‐AD ChN comparisons (Figure 5f; Figure S2), 6 were upregulated, 16 were downregulated, and 12 were expressed in opposing directions. The gene discussed is C4B; the disease is Alzheimer disease.