Moreover, proteins that modulate AMPA receptors Cacng8 (Log2 FC = −1.00), Lrrtm1 (Log2 FC = −1.34), Frrs1l (Log2 FC = −1.38), as well as NMDA receptors Grin2a (Log2 FC = −1.49), Clstn1 (Log2 FC = −1.05), were also downregulated by Ch‐ (Bhouri et al., 2018; Roy et al., 2016; Stewart et al., 2019), suggesting that Ch‐ can contribute to postsynaptic membrane dysfunction in AD. This evidence concerns the gene C4B and Alzheimer disease.