INS and Alzheimer disease: Relative to glucose metabolism impairments caused by Ch‐ in healthy aging and AD, we find that a plasma protein network associated with insulin binding (containing insulin‐degrading enzyme (Ide) and heat shock protein family D (Hspd1, also known as Hsp60)) was altered due to Ch‐ in 3xTg‐AD mice (Log2 FC = −1.92, −1.81, respectively).