VDAC1 and Alzheimer disease: Ch‐ in 3xTg‐AD mice downregulates Vdac1 (Log2 FC = −6.64) and Vdac2 (Log2 FC = −2.84): these two proteins have also been linked to mitochondrial dysfunction and AD pathology (Shoshan‐Barmatz et al., 2018; Singulani et al., 2020).