We found well‐known AD‐associated proteins altered by the 3xTg‐AD genotype, including upregulation of the amyloid precursor protein (App; Log2 FC = 1.58) and microtubule‐associated protein tau (Mapt), although Log2 FC was just under 1 (Log2 FC = 0.97), as well as downregulation of Apolipoprotein A1 (Apoa1; Log2 FC = −1.27), and Neuroplastin (Nptn; Log2 FC = −1.55). The gene discussed is APP; the disease is Alzheimer disease.