FDFT1 and gastroesophageal reflux disease: Further functional annotation and classification of DEGs participating in sesquiterpenoid and triterpenoid biosynthesis (map 00,909) (part of the gossypol synthesis pathway), were performed, and six enzymes, including LUP1 (EC.5.4.99.41), LUP2 (EC.5.4.99.39), SQLE (EC.1.14.14.17), FDFT1 (EC.2.5.1.21), GERD (EC.4.2.3.75), and CADS (EC.4.2.3.13) involved in the synthesis of gossypol, were found.