The efficacies of IHMT-337 and EPZ6438 in other EZH2-dependent DLBCL cell lines were also investigated, and the results showed that both IHMT-337 and EZP6438 robustly impaired EZH2-dependent DLBCL cell proliferation with similar GI50s (Fig. 1c and d). Here, EZH2 is linked to diffuse large B-cell lymphoma.