EZH2 and B-cell chronic lymphocytic leukemia: For example, in chronic lymphocytic leukemia, EZH2 occupies the Insulin Like Growth Factor 1 Receptor (IGF1R) promoter region along with Myc, upregulates IGF1R expression, and activates the downstream PI3Ks.55 In colon cancer cells, PCNA-associated factor (PAF) and EZH2 were found to be involved in Wnt signaling extra activation.56 Moreover, TRIM28 (also known as KRAB-associated protein 1 or KAP1) has previously been shown to promote breast cancer proliferation and metastatic progression.