STUB1 and diffuse large B-cell lymphoma: Moreover, using co-immunoprecipitation (co-IP), we detected a robust association of EZH2 with CHIP in the presence or absence of IHMT-337, in a dose-dependent manner, which support the conclusion of the increased binding between EZH2 and CHIP post-IHMT-337 treatment in different DLBCL cell lines (Supplementary Fig. S3d).