Interestingly, 15 Cer lipids, such as Cer d40:1 (m/z 656.576) and Cer d42:2 (m/z 682.593), were found to be overall significantly increased (|d| > 10) in abundance in control tumor tissue compared with treated tissue irrespective of acyl chain length or degree of unsaturation (Fig. 2A). This evidence concerns the gene CBLN1 and neoplasm.