SLC8B1 and colorectal carcinoma: We then blocked mitochondrial Ca2+ efflux through NCLX with CGP and found it did not prevent TG-induced OCR decrease (Fig. 9, G–I), reinforcing the role of mPTP and corroborating the results found in isolated mitochondria showing that CGP induces mPTP formation, leading to a decrease of CRC and negatively impacting mitochondrial respiration.