Ning Jiang et al. demonstrated that Rg1 downregulates hippocampal neuroinflammation and upregulates hippocampal neurogenesis by regulating SIRT1 and decreasing the level of acetylated p65 (ac-p65) in the hippocampus, thus serving to ameliorate depression-like behavior and hippocampal neuroinflammation induced by chronic social defeat stress [42]. The gene discussed is PPP1R3A; the disease is major depressive disorder.