NLRP3 and Keratoconjunctivitis sicca: Immunofluorescence showed that EX-527 inhibited the abolition of the relative fluorescence intensity of NLRP3 by luteolin (10 mg/kg) compared with luteolin (10 mg/kg) alone in the dry eye and depressive comorbid groups (p < 0.01) (Figure 4D).