In particular, TOSICA detects a pair of population-specific pathways (NOD1/2 SIGNALING PATHWAY and TOLL RECEPTOR CASCADES) that separate inflammation-related cDCs (cDC2_FCN1 and cDC2_IL1B) and a mature cDC subset (cDC3_LAMP3), which broadly present in tumor microenvironment (TME) from the rest of cDCs (Fig. 4c). The gene discussed is NOD1; the disease is neoplasm.