TOSICA’s TF regulon attentions in C3 and C4 show that AP2_Q6 and FOXO4_01 have low activities and AP4_01, MIR3617_5P, NFKB_Q6, and ATF3_Q6 have upregulated activities during COVID-19 disease progression (Fig. 5g). Here, TF is linked to COVID-19.