Moreover, mice with inhibited neuronal activity of the AgRP were more sensitive to DSS-induced colitis, characterized by a more severe weight loss, gross bleeding, shortened colon length, higher histological scores, and increased pro-inflammatory cytokine levels (Il6, Il1b, Il12, and Tgfb), compared with control mice (Fig. 2c–g and Supplementary Fig. 4c). This evidence concerns the gene IL6 and colitis.