In a prior study (2), MCC950 was gavaged daily 5 days/week (20 mg/kg/day, in saline) for 8 weeks in female foz/foz mice (which are hyperphagic due to a mutation in the Alms1 gene and develop severe obesity and hyperglycemia) following 16 weeks on an atherogenic diet. Here, ALMS1 is linked to obesity due to melanocortin 4 receptor deficiency.