It has been postulated that the NLRP3 inflammasome is also a key sensor of PAMPs/DAMPs in nonalcoholic fatty liver disease (NAFLD) and a trigger for necroinflammation and fibrosis, resulting in progression to fibrosing nonalcoholic steatohepatitis (NASH) (1). The gene discussed is NLRP3; the disease is metabolic dysfunction-associated steatotic liver disease.