NLRP3 and Hepatic fibrosis: The Nlrp3 KO mice also developed fibrosing NASH with similar elevated levels of plasma ALT, AST, and ALP compared to the WT mice, similar levels of hepatic steatosis, and slightly higher levels of hepatic inflammation grade and hepatic fibrosis by histological staging and quantitative Sirius red staining—a difference that was not statistically significant (Table 1).