NLRP3 and metabolic dysfunction-associated steatohepatitis: It has been postulated that the NLRP3 inflammasome is also a key sensor of PAMPs/DAMPs in nonalcoholic fatty liver disease (NAFLD) and a trigger for necroinflammation and fibrosis, resulting in progression to fibrosing nonalcoholic steatohepatitis (NASH) (1).