GPT and Hepatic fibrosis: Compared to mice on a 0.75% cholesterol diet that were not treated with MCC950, those that were treated with MCC950 in their drinking water had lower liver weight and plasma cholesterol, similar levels of plasma ALT, AST and ALP, similar levels of hepatic steatosis and inflammation and slightly lower levels of hepatic fibrosis by quantitative Sirius red staining or by histological stage that were not statistically significant (Table 2 and Fig. 3).