Decreased PSD95 but normal synaptophysin puncta levels in CA1 have been reported previously.69 In contrast, reduced synaptophysin levels have also been observed in the same model.70 Similarly, normal spine densities in the CA1 region of J20 mice at the same age have also been reported.71 Interestingly, an early increase in excitatory synaptic density in CA1 has been reported in a different amyloid model.47 These results indicate that structural synaptic alterations in apical and basal dendrites may depend on the age, circuit, strain, and, perhaps, sub-strain in amyloidosis. The gene discussed is SYP; the disease is amyloidosis.