Previous studies reported that the possession of the APOE ε4 allele was associated with unfavorable outcome in chronic central nervous system disorders, including Alzheimer’s disease [7], Parkinson’s disease [8], amyotrophic lateral sclerosis [9, 10], as well as in acute brain injuries including intracerebral hemorrhage [11] and post stroke dementia [12]. This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.