However, AREG and bFGF protein levels were highly expressed in only 15 (35.71%) and 19 (45.24%) of 42 tongue cancer tissues with relatively low XBP1s expression, respectively (Figures 6B and S8A), suggesting a positive correlation between XBP1s and AREG and bFGF protein expression in tongue cancers. This evidence concerns the gene AREG and tongue cancer.