IL6 and neoplasm: However, when anti-IL-6 receptor (IL-6R Ab) or anti IL-6 (IL-6 Ab) blocking antibodies were added to EV-depleted CM derived from B16-F10 cells, reduced miR-214 induction was observed in CAFs, compared to control immunoglobulin (IgG) treatments (Fig. 7C-D), thus suggesting that IL-6 is secreted in tumor-stroma cell co-cultures and is used for the accumulation of miR-214 in stroma cells.