To assess the relevance of miR-214/IL-6/STAT3 axis in human tumors, the correlation between miR-214 and IL-6 or STAT3 expression was evaluated in various signatures of melanoma and breast cancer samples and miR-214 resulted positively correlated (p-value < 0.05) with IL-6 and STAT3 expression in all the signatures analyzed [34, 36] as in Fig. 7E and Fig. S13A-B. The gene discussed is STAT3; the disease is melanoma.