Although it is worth mentioning that amplitude generally increase as frequencies decreases, here, the presence of aberrant theta spectral power in both DEPDC5 and NPRL3 epileptic patients align with the growing body of research highlighting aberrant theta oscillations; in adults with genetic and neurological disorders [53] including FXS [43, 54] and generalized epilepsy [55, 56]. Here, NPRL3 is linked to generalized epilepsy.