In this study, we found that SLC7A2 expression was down-regulated in both LUAD and LUSC as well as NSCLC cell line, like A549 and lower SLC7A2 expression was associated with worse RFS in NSCLC patients (GES31210, GES8894 and TCGA database). Here, SLC7A2 is linked to non-small cell lung carcinoma.