Moreover, PrognoScan database also showed that lower SLC7A2 expression in lung cancer cohorts (GSE31210, n = 204 and GSE8894, n = 138) was associated with a worse prognosis and the probability of RFS in lower SLC7A2 group was significantly lower than that of those in higher group (HR =  − 0.32, 95% CI = 0.57–0.92, Cox P = 0.0091; HR = 1.34, 95% CI = 1.42–10.25, Cox P = 0.008; HR =  − 9.07, 95% CI = 0.00–0.34, Cox P = 0.0259) (Fig. 6F–H). Here, SLC7A2 is linked to lung carcinoma.