In contrast, the expression of TPM4 was significantly lower than that in normal control tissues in bladder urothelial carcinoma (BLCA), kidney chromophobe (KICH), kidney renal papillary cell carcinoma (KIRP), lung adenocarcinoma (LUAD), skin cutaneous melanoma (SKCM), uterine corpus endometrial carcinoma (UCEC) and uterine carcinosarcoma (UCS) (Fig. 1A). Here, TPM4 is linked to bladder transitional cell carcinoma.