TPM4 and central nervous system cancer: Furthermore, a comparison of TPM4 expression in gliomas with and without chromosome 1p and 19q codeletion and gliomas with wild-type and mutant IDH showed that TPM4 expression in gliomas without chromosome 1p/19q codeletion was higher and significantly higher in IDH-wild-type gliomas than in IDH-mutant gliomas (Fig. 3B-C).