Interestingly, results showed that the protein expression level of p-ERK and p-AKT was upregulated in the circIFNGR2 overexpressed group of WT-KRAS cells, while the protein expression level of p-ERK and p-AKT showed little difference in the MUT-KRAS CRC cells groups. The gene discussed is KRAS; the disease is colorectal carcinoma.