The results showed that the protein expression level of p-ERK and p-AKT was upregulated in the circIFNGR2 overexpressed group of WT-KRAS cells (Fig. 5d), while the protein expression level of p-ERK and p-AKT showed little difference in the MUT-KRAS CRC cells groups (Fig. 5f). This evidence concerns the gene KRAS and colorectal carcinoma.