Although it has been reported that exosomes from colon cancer induce cancer invasion by regulating fibroblast focal adhesion protein and its actin cytoskeleton regulators, including NCKAP1 [30], NCKAP1 as a blood diagnostic marker in CRC is not yet known, and its metastatic mechanism has not been identified. This evidence concerns the gene NCKAP1 and malignant colon neoplasm.