PKM and colonic neoplasm: However, Huang et al. found that HOXB-AS3 was a tumour suppressor as a small peptide rather than a lncRNA by competitively binding to the arginine residues in an RNA-binding RGG box motif of hnRNP A1, which could bind to the sequences flanking PKM exon 9 to promote PKM2 formation, suppressing cancer growth as well as glycolysis in colon cancer [133] (Fig. 3, Table 1).