The 47 genes recurrently annotated in the significant pathways were upregulated in early/late phenotype changes and AD maturation and slightly downregulated in WT maturation, including integrin genes (Itga1, Itga6, and Itgb1), fibronectin 1 (Fn1), angiopoietin 1 (Angpt1), and angiopoietin-1 receptor (Tek) (Fig. 3c). This evidence concerns the gene ITGA6 and Alzheimer disease.