In addition to the Wnt/beta-catenin pathway, cross-presentation by mature dendritic cells also contributes to CD8+ T cell activation [37], and the expression of C-C chemokine receptor 7 (Ccr7) in conventional dendritic cells (cDCs) plays an important role in delivering intact tumor antigen to tumor-draining lymph nodes [38] and is also a marker in the maturation of dendritic cells [39]. This evidence concerns the gene CD8A and neoplasm.