For example, the upregulation of SF3B4 promotes tumorigenesis in hepatocellular carcinoma (HCC) [12], esophageal squamous cell carcinoma (ESCC) [13], and ovarian cancer (OC) [14], whereas its downregulation or depletion results in pancreatic cancer [15] and breast cancer in NS patient [16]. This evidence concerns the gene SF3B4 and hepatocellular carcinoma.