Furthermore, NSCLC patients with high three signatures (STRIP2, IGF2BP3 and TMBIM6) expression manifested a shorter overall survival (n = 478, HR = 1.9, P = 4e-05) and disease-free survival (n = 478, HR = 1.5, P = 0.012) than patients with low three signatures expression (Fig. 10h). The gene discussed is STRIP2; the disease is non-small cell lung carcinoma.