Furthermore, TMBIM6 expression was positively correlated with STRIP2 and IGF2BP3 expression, and patients with high expression of the three gene signatures group show poorer overall survival and disease free survival than those patients with low expression of three gene signatures group, suggesting STRIP2-IGF2BP3-TMBIM6 axis has an important role in NSCLC progression and provides a novel potential prognostic biomarker for NSCLC. Here, IGF2BP3 is linked to non-small cell lung carcinoma.