Furthermore, EA reduced the infarct area and increased the ejection fraction (EF) by inhibiting the expression of NLR family pyrin domain containing 3 (NLRP3) and AMP-activated protein kinase (AMPK)-dependent autophagy in an animal study of an acute myocardial infarction rat model [57, 58]. This evidence concerns the gene NLRP3 and acute myocardial infarction.