While no significant correlation was found in the sPD-L1 cohort (the plasma samples of six patients were inadequate, and only the levels of secPD-L1 and exoPD-L1 were detected), secPD-L1 was positively associated with mucinous adenocarcinoma or signet-ring cell carcinoma. This evidence concerns the gene SPDL1 and signet ring cell carcinoma.